CellPress published a special issue to celebrate the 40th anniversary of Trends in Biotechnology. This issue provided expert commentary on a wide variety of biological technologies with perspectives on their development over the past decade, the current state of the technologies, and hypothetical future advances.

A review paper titled "Synthetic biology of extremophiles: a new wave of biomanufacturing" that came from PhaBuilder was also embodied in it. In this paper, we review increasing numbers of products already manufactured utilizing extremophiles in recent years. In addition, genetic parts, molecular tools, and manipulation approaches for extremophile engineering are also summarized, and challenges and opportunities are predicted for non-conventional chassis. Next-generation industrial biotechnology (NGIB) based on engineered extremophiles promises to simplify biomanufacturing processes and achieve open and continuous fermentation, without sterilization, and utilizing low-cost substrates, making NGIB an attractive green process for sustainable manufacturing.

NGIB, which is also the main technology used in PhaBuilder currently. Based on this technology, PhaBuilder has successfully reduced the energy consumption of traditional biological manufacturing and greatly improved the manufacturing efficiency. And we have received orders from customers all over the world after the successful trial production launched in 2022.

NGIB as the core of new biological manufacturing engine, PhaBuilder will continue to promote the realization of the "From Micro to Future" concept, explore more PHA life application scenarios. We hope to have a far-reaching impact on industrial development.